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Dimeric Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Anti-Hepatitis B Virus Activities

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posted on 28.06.2016, 00:00 by Yu-Bo Zhang, Li-Qin Zhan, Guo-Qiang Li, Feng Wang, Ying Wang, Yao-Lan Li, Wen-Cai Ye, Guo-Cai Wang
Six unusual matrine-type alkaloid dimers, flavesines A–F (1–6, respectively), together with three proposed biosynthetic intermediates (7–9) were isolated from the roots of Sophora flavescens. Compounds 1–5 were the first natural matrine-type alkaloid dimers, and compound 6 represented an unprecedented dimerization pattern constructed by matrine and (−)-cytisine. Their structures were elucidated by NMR, MS, single-crystal X-ray diffraction, and a chemical method. The hypothetical biogenetic pathways of 1–6 were also proposed. Compounds 1–9 exhibited inhibitory activities against hepatitis B virus.