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Diastereoselective and Enantioselective Synthesis of Unsymmetric β,β-Diaryl-α-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides

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posted on 25.05.2016, 00:00 by Xiang-Zhi Zhang, Yu-Hua Deng, Xu Yan, Ke-Yin Yu, Fang-Xin Wang, Xiao-Yan Ma, Chun-An Fan
A novel strategy based on phase transfer catalysis for the diastereoselective and enantioselective direct assembly of unsymmetric β,β-diaryl-α-amino acid esters via 1,6-conjugate addition of para-quinone methides and glycine derivatives is described. This protocol also provides an alternative route to the synthetically interesting functionalized chiral tetrahydroisoquinoline and its analogues.

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