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Diastereoselective and Enantioselective Conjunctive Cross-Coupling Enabled by Boron Ligand Design

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posted on 30.10.2018, 00:00 by Jesse A. Myhill, Christopher A. Wilhelmsen, Liang Zhang, James P. Morken
Enantio- and diastereoselective conjunctive cross-coupling of β-substituted alkenylboron “ate” complexes is studied. Whereas β-substitution shifts the chemoselectivity of the catalytic reaction in favor of the Suzuki–Miyaura product, use of a boronic ester ligand derived from acenaphthoquinone allows the process to favor the conjunctive product, even with substituted substrates.