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Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (−)-Salinosporamide A

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posted on 17.12.2015, 03:48 by Angus W. J. Logan, Simon J. Sprague, Robert W. Foster, Léo B. Marx, Vincenzo Garzya, Michal S. Hallside, Amber L. Thompson, Jonathan W. Burton
A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported. The methodology is demonstrated in a formal synthesis of (−)-salinosporamide A.

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