Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe2)3‑Mediated Reductive Cyclopropanation
dataset
posted on 2014-11-07, 00:00 authored by Rong Zhou, Changjiang Yang, Yiyi Liu, Ruifeng Li, Zhengjie HeA P(NMe2)3-mediated reductive cyclopropanation
reaction of α-keto esters or amides with isatin-derived alkenes
has been developed, providing efficient and diastereoselective synthesis
of highly functionalized spirocyclopropyl oxindoles bearing two all-carbon
quaternary centers. This reaction also represents a complementary
and nonmetal-involving protocol for the challenging cyclopropanation
of electron-deficient alkenes.
