ol303200n_si_002.cif (13.81 kB)
Download file

Diastereoselective Synthesis of CF3‑Substituted, Epoxide-Fused Heterocycles with β‑(Trifluoromethyl)vinylsulfonium Salts

Download (13.81 kB)
dataset
posted on 20.02.2016, 03:27 authored by Sven P. Fritz, Thomas H. West, Eoghan M. McGarrigle, Varinder K. Aggarwal
CF3-substituted vinyl diphenylsulfonium triflate is an effective annulation reagent for the formation of α-CF3 substituted, epoxide-fused heterocycles (pyrrolidines, piperidines, and tetrahydrofurans). This simple method affords a variety of valuable heterocyclic building blocks in a highly diastereoselective manner (dr >20:1).

History