ol5b02097_si_002.cif (340.47 kB)
Diastereoselective Fluorocyclopropanation of Chiral Allylic Alcohols Using an α‑Fluoroiodomethylzinc Carbenoid
dataset
posted on 2015-09-04, 00:00 authored by Chandrasekhar Navuluri, André B. CharetteChiral fluorocyclopropyl
carbinols were synthesized in high diastereoselectivities
via a zinc mediated cyclopropanation reaction, using sec-allylic alcohols as simple building blocks. An enantioselective
version of this transformation was achieved through in situ formation of chiral allylic zinc sec-alkoxides
from the requisite aldehydes using Walsh’s protocol.