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Diastereoselective Diels−Alder Reactions with an Allenyl-Containing Spiro-Amido Chiral Auxiliary

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posted on 05.02.2010, 00:00 by Jeff R. Henderson, Julian P. Chesterman, Masood Parvez, Brian A. Keay
A novel allenyl-containing 1,3-spiro-amido alcohol auxiliary has been prepared and used in a variety of diastereoselective Diels−Alder reactions providing exclusively endo adducts with diastereomeric ratios ranging from 2:1 to >99:1.