Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2‑Alkylazaarenes to N‑Boc Imines and Nitroalkenes

2012-11-07T00:00:00Z (GMT) by Daniel Best Szymon Kujawa Hon Wai Lam
A chiral Pd­(II)–bis­(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkyl­aza­arenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.