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Development of a New Family of Chiral Auxiliaries

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posted on 17.04.2015, 00:00 by Fabien Gelat, Vincent Richard, Olivier Berger, Jean-Luc Montchamp
A new family of chiral auxiliaries designed on a conformationally restricted version of (−)-8-phenylmenthol has been developed. Both enantiomers are available from an inexpensive synthesis conducted on multigram scale. A first application has showed comparable diastereoselectivity between the novel auxiliary and (−)-8-phenylmenthol.