American Chemical Society
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Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications

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posted on 2015-11-20, 00:00 authored by Steven A. Weissman, Neal G. Anderson
Statistical design of experiments (DoE) is a powerful tool for optimizing processes, and it has been used in many stages of API development. This review summarizes selected publications from Organic Process Research & Development using DoE to show how processes can be optimized efficiently and how DoE findings may be applied to scale-up.