jo9b02596_si_006.cif (365.77 kB)

Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives

Download (365.77 kB)
posted on 26.11.2019 by Maksym Bugera, Serhii Trofymchuk, Karen Tarasenko, Olga Zaporozhets, Yurii Pustovit, Pavel K. Mykhailiuk
A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids is developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers.