np0c01103_si_003.zip (16.85 MB)
Download fileDenigrins and Dactylpyrroles, Arylpyrrole Alkaloids from a Dactylia sp. Marine Sponge
dataset
posted on 05.11.2020, 21:52 authored by Unwoo Kang, Laura K. Cartner, Dongdong Wang, Chang-Kwon Kim, Cheryl L. Thomas, Girma M. Woldemichael, Berkley E. Gryder, John F. Shern, Javed Khan, Cristiana Castello-Branco, Edward C. Sherer, Xiao Wang, Erik L. Regalado, Kirk R. GustafsonSeven new arylpyrrole alkaloids (1–7), along with four known compounds, were isolated from an extract
of a Dactylia sp. nov. marine sponge, and their structures
were elucidated by interpretation of NMR and MS spectroscopic data.
Denigrins D–G (1–4) have highly
substituted pyrrole or pyrrolone rings in their core structures, while
dactylpyrroles A–C (5–7) have
tricyclic phenanthrene cores. Due to the proton-deficient nature of
these scaffolds, key heteronuclear correlations from 1H–15N HMBC and LR-HSQMBC NMR experiments were used in the structure
assignment of denigrin D (1). Dictyodendrin F (8), a previously described co-metabolite, inhibited transcription
driven by the oncogenic PAX3-FOXO1 fusion gene with an IC50 value of 13 μM.