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Dehydrative Allylation of α C(sp3)–H Bonds of Alkylamines with Allylic Alcohols

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posted on 21.05.2020 by Yusuke Masuda, Misato Ito, Masahiro Murakami
Herein reported is a dehydrative coupling reaction of alkyl amines with allylic alcohols promoted by co-operation of photoredox and palladium catalysts. A range of homoallylic amines are efficiently synthesized. A mechanistic study suggests that an in situ generated carboxylic acid activates an allylic alcohol to facilitate its oxidative addition onto palladium.

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