ol5b02403_si_004.cif (2.2 MB)

Dearomative Indole Bisfunctionalization via a Diastereoselective Palladium-Catalyzed Arylcyanation

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posted on 02.10.2015 by David A. Petrone, Andy Yen, Nicolas Zeidan, Mark Lautens
The first Pd-catalyzed dearomative indole bisfunctionalization via a diastereoselective arylcyanation is reported. This method facilitates the formation of diverse indoline scaffolds bearing congested stereocenters with high levels of diastereoselectivity. This also represents the first example of a cyanation mechanism involving a 2° benzylic Pd­(II) intermediate.