American Chemical Society

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Daphnane- and Tigliane-Type Diterpenoid Esters and Orthoesters from Pimelea elongata

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posted on 2010-11-29, 00:00 authored by Patricia Y. Hayes, Sharon Chow, Michael J. Somerville, Mary T. Fletcher, James J. De Voss
Investigation of Pimelea elongata (“Lakebed Pimelea”) afforded 18 tigliane- and daphnane-type diterpenes (118). Eight of these were new compounds: four (13, 5) tigliane esters and four (7, 8, 10, 11) daphnane orthoesters. The 10 known compounds were 12-O-decanoylphorbol-13-acetate (4), P. simplex subtoxin B (6), wikstroelide E (9), pimelotides A and B (12, 13), gnidiglaucin (14), simplexin (15), huratoxin (16), kirkinine D (17), and 12-β-acetoxyhuratoxin (18). The structures and relative configurations of the new compounds were determined by 1D and 2D NMR spectroscopic studies in combination with MS analyses.