Cytotoxic Styryl-Lactones from the Leaves and Twigs of Polyalthia crassa
datasetposted on 27.12.2006, 00:00 authored by Patoomratana Tuchinda, Bamroong Munyoo, Manat Pohmakotr, Pongchan Thinapong, Samaisukh Sophasan, Thawatchai Santisuk, Vichai Reutrakul
Four new styryl-lactones, crassalactones A−D (1−4), were isolated from a cytotoxic ethyl acetate-soluble extract of the leaves and twigs of Polyalthia crassa, together with seven known compounds, (+)-3-acetylaltholactone, (+)-altholactone, aristolactam AII, cinnamic acid, (+)-goniofufurone, (+)-goniopypyrone, and (+)-howiinol A. Their structures were determined on the basis of spectroscopic methods. The absolute configuration of 1−3 was established by chemical conversions. Single-crystal X-ray analysis and the Mosher ester method were used to confirm the absolute stereochemistry of 4. Cytotoxic evaluation against several mammalian cancer cell lines was performed on all new isolates, aristolactam AII, and the modified (+)-tricinnamate derivative 11 obtained from 1.
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cancer cell lines4. Cytotoxic evaluationacetylaltholactonegoniofufuroneacidethylconversionbasischemicalaltholactoneMosher ester methodaristolactam AIItricinnamateTwigscinnamicLeavePolyalthiacrassalactonestereochemistrycompoundspectroscopicconfigurationcytotoxiccrassaFourcrassatwigsanalysis1.howiinolgoniopypyrone