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Cu(TFA)2‑Catalyzed Oxidative Tandem Cyclization/1,2-Alkyl Migration of Enamino Amides for Synthesis of Pyrrolin-4-ones

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posted on 2013-09-20, 00:00 authored by Zhi-Jing Zhang, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan
A novel Cu(TFA)2-catalyzed oxidative tandem cyclization/1,2-alkyl migration of readily available enamino amides for the synthesis of pyrrolin-4-ones has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of substituted pyrrolin-4-ones in high yields under mild conditions.