ol6b01343_si_002.cif (397.92 kB)

Cu(OAc)2‑Mediated Cascade Annulation of Diarylalkyne Sulfonamides through Dual C–N Bond Formation: Synthesis of 5,10-Dihydro­indolo­[3,2‑b]indoles

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posted on 01.07.2016, 18:20 by Junchao Yu, Daisy Zhang-Negrerie, Yunfei Du
An unusual cascade reaction featuring annulation of diarylalkyne sulfonamides to form 5,10-dihydro­indolo­[3,2-b]­indoles has been realized with Cu­(OAc)2 as the sole oxidant. This unprecedented process encompasses two sequential C–N bond formations, allowing for an efficient synthesis of the biologically important indoloindole derivatives.