American Chemical Society
ol7b02121_si_005.cif (232.35 kB)

CuCl/Et3N‑Catalyzed Synthesis of Indanone-Fused 2‑Methylene Pyrrolidines from Enynals and Propargylamines

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posted on 2017-08-21, 12:37 authored by Shaotong Qiu, Lianfen Chen, Huanfeng Jiang, Shifa Zhu
An efficient CuCl/Et3N-catalyzed tandem reaction for the synthesis of indanone-fused pyrrolidine was developed. In this process, two rings and four bonds are generated in one pot with high atom-economy and step-efficiency. The addition of Et3N was found as the key factor for the success of the tandem reaction.