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Copper-Catalyzed β‑Trifluoromethylation of Conjugated Hydrazones

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posted on 19.09.2014, 00:00 by Alexis Prieto, Emeric Jeamet, Nuno Monteiro, Didier Bouyssi, Olivier Baudoin
The Cu-catalyzed direct β-trifluoromethylation of α,β-unsaturated aldehyde N,N-dibenzylhydrazones with Togni hypervalent iodine reagent is described. The reaction yields stereodefined CF3-alkenyl derivatives under mild conditions and is proposed to proceed via a radical process.