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Copper-Catalyzed Oxidative Ring Closure and Carboarylation of 2‑Ethynylanilides

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posted on 15.11.2013, 00:00 by Ádám Sinai, Ádám Mészáros, Tamás Gáti, Veronika Kudar, Anna Palló, Zoltán Novák
A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C–O and C–C bonds.