Copper-Catalyzed Desymmetric Intramolecular Ullmann C–N Coupling: An Enantioselective Preparation of Indolines
datasetposted on 05.09.2012, 00:00 by Fengtao Zhou, Jiajia Guo, Jianguang Liu, Ke Ding, Shouyun Yu, Qian Cai
The first highly enantioselective copper-catalyzed intramolecular Ullmann C–N coupling reaction has been developed. The asymmetric desymmetrization of 1,3-bis(2-iodoaryl)propan-2-amines catalyzed by CuI/(R)-BINOL-derived ligands led to the enantioselective formation of indolines in high yields and excellent enantiomeric excesses. This method was also applied to the formation of 1,2,3,4-tetrahydroquinolines in high yields and excellent enantioselectivity.