Copper-Catalyzed Aerobic Spirocyclization of Biaryl-N-H-imines via 1,4-Aminooxygenation of Benzene Rings
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posted on 2012-07-06, 00:00 authored by Ya Lin Tnay, Cheng Chen, Yi Yuan Chua, Line Zhang, Shunsuke ChibaA synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.
