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Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2‑a]pyridines

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posted on 19.06.2017, 13:12 by Vikas Dwivedi, Ravi Kumar, Kavita Sharma, Balasubramanian Sridhar, Maddi Sridhar Reddy
A facile access to 3-heterosubstituted (3-oxazolidinonyl/indolyl/phenoxy) imidazo­[1,2-a]­pyridines from readily available 2-aminopyridines and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol ethers is achieved via Cu­(OTf)2-mediated intermolecular diamination under aerobic conditions. The reaction is highly regioselective, owing to internal electron bias, and thus led to a single regioisomer with heterosubstitution at C3.