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Copper-Catalyzed Trifluoromethylation of Alkenes with Redox-Neutral Remote Amidation of Aldehydes

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posted on 06.06.2016, 20:31 by Cungui Cheng, Shuiyou Liu, Danyang Lu, Gangguo Zhu
A room-temperature and one-pot synthesis of ε-CF3-substituted amides via the copper-catalyzed trifluoromethylation of alkenes with redox-neutral remote amidation of aldehydes is described. This reaction is featured by an unprecedented 1,5-H atom abstraction from aldehydic C–H bonds by α-CF3-alkyl radicals resulting from the radical trifluoromethylation of alkenes, thus enabling a new possibility of the trifluoromethylation-initiated remote sp2 C–H functionalization.