cs9b02931_si_004.cif (591.36 kB)
Copper-Catalyzed Diastereoselective and Enantioselective Addition of 1,1-Diborylalkanes to Cyclic Ketimines and α‑Imino Esters
dataset
posted on 2019-08-19, 16:48 authored by Jeongho Kim, Minkyeong Shin, Seung Hwan ChoWe
report broadly applicable copper catalytic conditions for the
diastereoselective and enantioselective 1,2-addition of 1,1-diborylalkanes
to cyclic ketimines and α-imino esters. The developed method
provides various β-aminoboronate esters bearing adjacent stereocenters
with high diastereo- and enantioselectivity. Synthetic applications
for converting the obtained β-aminoboronate esters to a diverse
array of synthetically useful chiral compounds are demonstrated.