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Copper-Catalyzed Cross-Dehydrogenative N2‑Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N‑Amidoalkylation of NH-1,2,3-Triazoles

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posted on 30.05.2017, 00:00 by Xiaocong Deng, Xue Lei, Gang Nie, Lihui Jia, Yuanxiang Li, Yunfeng Chen
An efficient copper-catalyzed C–N bond formation by N–H/C–H cross-dehydrogenative coupling (CDC) between NH-1,2,3-triazoles and N,N-dialkylamides has been developed. The method provided N-amidoalkylated 1,2,3-triazoles with moderate to high yields, and the reactions showed high N2-selectivities when 4,5-disubstituted NH-1,2,3-triazoles served as the substrates.