posted on 2005-08-15, 00:00authored byFuk Yee Kwong, Chi Wai Lai, Michael Yu, Duan-Ming Tan, Fuk Loi Lam, Albert S. C. Chan, Kin Shing Chan
A convenient recipe for the direct preparation of functionalized tertiary arsines has been
developed by simple palladium-catalyzed arsination of aryl triflates using triphenylarsine
as the arsinating agent. This catalytic arsination was conducted under neutral reaction
conditions and was found to be compatible with various functional groups, such as aldehyde,
ester, keto, nitrile, and nitro groups. Interestingly, these reactions can be carried out in
either DMF or solvent-free conditions with similar reaction rates and product yields. A
notable arsination product, (2-cyanophenyl)diphenylarsine, underwent condensation with
optically active 2-aminoalkyl alcohols in the presence of ZnCl2 catalyst to afford new chiral
As,N ligands. The bidentate As,N-free ligand 14 and the Pt-As,N complex 18 were
characterized by single-crystal X-ray crystallography.