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Consecutive Gold(I)-Catalyzed Cyclization Reactions of o‑(Buta-1,3-diyn-1-yl-)-Substituted N‑Aryl Ureas: A One-Pot Synthesis of Pyrimido[1,6‑a]indol-1(2H)‑ones and Related Systems

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posted on 07.06.2013, 00:00 by Phillip P. Sharp, Martin G. Banwell, Jens Renner, Klaas Lohmann, Anthony C. Willis
Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.

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