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Conformational Control of Transmembrane Cl- Transport

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posted on 21.02.2007, 00:00 by Paul V. Santacroce, Jeffery T. Davis, Mark E. Light, Philip A. Gale, José Carlos Iglesias-Sánchez, Pilar Prados, Roberto Quesada
Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.