ol9003965_si_001.cif (22.1 kB)

Concise Synthesis of Tricyclic Isoindolinones via One-Pot Cascade Multicomponent Sequences

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posted on 16.04.2009, 00:00 by Raouf Medimagh, Sylvain Marque, Damien Prim, Jérôme Marrot, Saber Chatti
A series of enantiopure tricyclic isoindolinones has been successfully synthesized through a one-pot selective cascade process from furan derivatives. The synthesis is straightforward and gave good overall yields taking into account the concomitant formation of five C−C, C−O, and C−N bonds. The strategy was extended to the preparation of a thiazolidine analogue.

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