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Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24

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posted on 26.06.2015, 00:00 by Haibo Zhou, Liyuan Li, Wei Wang, Qian Che, Dehai Li, Qianqun Gu, Tianjiao Zhu
Two new meroterpenoids, named chrodrimanins I and J (1 and 2), together with five known biosynthetically related chrodrimanins (37), were isolated from the culture of the Antarctic moss-derived fungus Penicillium funiculosum GWT2-24. Distinguished from all of the reported chrodrimanins, compounds 1 and 2 possess a unique cyclohexanone (E ring) instead of a δ-lactone ring. These structures including the absolute configurations were established on the basis of MS, NMR, and X-ray crystallographic analysis. Compounds 17 showed no cytotoxic or antibacterial activities, while the known compounds 3, 5, and 6 exhibited inhibitory activities against influenza virus A (H1N1), with IC50 values ranged from 21 to 57 μM.