np8b00418_si_002.cif (955.82 kB)
Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus
dataset
posted on 2019-02-06, 14:47 authored by Bai Bai, Shao-Xia Ye, De-Po Yang, Long-Ping Zhu, Gui-Hua Tang, Yun-Yun Chen, George Qian Li, Zhi-Min ZhaoChloraserrtone A (1),
a new sesquiterpenoid dimer
with two lindenane-type sesquiterpenoid monomers bridged by two six-membered
rings, was obtained from Chloranthus serratus. A
combination of UV, IR, NMR, HRESIMS, and X-ray diffraction data were
used to elucidate the structure of 1. Compound 1 represents the first lindenane-type sesquiterpenoid dimer
with extremely unique C-15–C-15′, C-4–C-6′,
and C-6–C-11′ linkages to form two six-membered rings
between the monomeric units. A plausible biosynthesis toward chloraserrtone
A is proposed. This new compound (1), together with the
known lindenane dimers (2–11), were
assessed for their inhibitory effects on lipopolysaccharide-induced
NO production in RAW264.7 cells. Compound 6 showed activity
with an IC50 value of 3.7 μM.