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Chiral Phosphoric Acid-Catalyzed Enantioselective and Diastereoselective Spiroketalizations

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posted on 20.02.2016, 21:44 by Zhankui Sun, Grace A. Winschel, Alina Borovika, Pavel Nagorny
Catalytic enantioselective and diastereoselective spiroketalizations with BINOL-derived chiral phosphoric acids are reported. The chiral catalyst can override the inherent preference for the formation of thermodynamic spiroketals, and highly selective formation of nonthermodynamic spiroketals could be achieved under the reaction conditions.