American Chemical Society
ja109069k_si_001.cif (18.55 kB)

Chiral Bicycle Imidazole Nucleophilic Catalysts: Rational Design, Facile Synthesis, and Successful Application in Asymmetric Steglich Rearrangement

Download (18.55 kB)
posted on 2010-11-17, 00:00 authored by Zhenfeng Zhang, Fang Xie, Jia Jia, Wanbin Zhang
A new type of chiral bicycle imidazole nucleophilic catalyst was rationally designed, facilely synthesized, and successfully applied in an asymmetric Steglich rearrangement with good to excellent yield and enantioselectivity at ambient temperature. Moreover, it can be easily recycled with almost no reduction of catalytic efficiency. This is the first example for the successful chiral imidazole nucleophilic catalyst without H-bonding assistance.