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Chemoselective Hydrogenation of Imides Catalyzed by Cp*Ru(PN) Complexes and Its Application to the Asymmetric Synthesis of Paroxetine

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posted on 17.01.2007, 00:00 by Masato Ito, Ayaka Sakaguchi, Chika Kobayashi, Takao Ikariya
This work represents the first catalytic hydrogenation of imides into amides and primary alcohols, in which the unique chemoselectivity is originated from the bifunctional nature of ruthenium-NH moiety in the catalyst.