posted on 2019-09-04, 18:00authored byXing Liu, Zhi-Bing Dong
An
efficient Chan–Lam-type methodology for the selective
synthesis of S-arylbenzimidazoles and N,S-diarylbenzimidazoles was developed. The selectivity
was controlled by varying the amount of the catalyst Cu(OAc)2·H2O, temperature, and solvent switching. These transformations
feature a simple protocol, broad functional group tolerance, high
selectivity, and good to excellent yields. It is noteworthy that these
reactions represent the first examples of the application of the selective
Chan–Lam coupling.