American Chemical Society
ja9b03806_si_005.cif (652.89 kB)

Chalcogen–Chalcogen Bonding Catalysis Enables Assembly of Discrete Molecules

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posted on 2019-05-24, 00:00 authored by Wei Wang, Haofu Zhu, Shuya Liu, Zhiguo Zhao, Liang Zhang, Jingcheng Hao, Yao Wang
Despite the observation of noncovalent interactions between chalcogen atoms in X-ray crystal structures, catalysis that harnesses the power of such chalcogen–chalcogen bonding interactions to produce advanced molecules remains an unresolved problem. Here, we show that a class of extraordinary chalcogen-bonding catalysts enables assembly of discrete small molecules including three β-ketoaldehydes and one indole, leading to the construction of N-heterocycles in a highly efficient manner. The strong activation ability of these rationally designed catalysts provides a general solution to the intrinsic limitations of chalcogen bonding catalysis.