jo8b01622_si_003.cif (516.81 kB)
Download fileCatalytic Asymmetric [3 + 2] Cycloaddition Reaction between Aurones and Isocyanoacetates: Access to Spiropyrrolines via Silver Catalysis
dataset
posted on 2018-07-11, 00:00 authored by Zhi-Peng Wang, Sichuan Xiang, Pan-Lin Shao, Yun HeThe
first enantioselective formal [3 + 2] cycloaddition of aurone
analogues with isocyanoacetates was developed via chiral Ag-complex
catalysis. A variety of optically enriched spiro-1-pyrrolines were
obtained in excellent yields, diastero- and enantioselectivities (up
to 99% yield, >20:1 dr, >99% ee). This synthetic
approach represents an extremely simple, efficient, and atom-economical
method for spiro-1-pyrrolines synthesis.