ol5b02052_si_001.cif (22.8 kB)
Catalytic Asymmetric [3 + 2] Cyclization Reactions of 3‑Isothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst
dataset
posted on 2015-09-04, 00:00 authored by Linqing Wang, Dongxu Yang, Dan Li, Xihong Liu, Qian Zhao, Ranran Zhu, Bangzhi Zhang, Rui WangA highly
enantioselective formal [3 + 2] cycloaddition reaction
between 3-isothiocyanato oxindoles and alkynyl ketones is reported
for the first time. An oxazoline–OH type chiral ligand derived
from o-hydroxy-phenylacetic acid is employed to generate
an effective magnesium catalyst in the current cyclization reaction
and give serials of chiral spirooxindoles with good chemical yields
and enantioselectivities.