jo501961h_si_001.cif (20.4 kB)
Catalyst-Free and Selective C–N Bond Functionalization: Stereospecific Three-Component Coupling of Amines, Dichloromethane, and >P(O)H Species Affording α‑Aminophosphorus Compounds
dataset
posted on 2015-01-02, 00:00 authored by Yalei Zhao, Xiuling Chen, Tieqiao Chen, Yongbo Zhou, Shuang-Feng Yin, Li-Biao HanCatalyst-free
and selective C–N bond functionalization has
been achieved through three-component coupling of amines, dihalomethane,
and >P(O)H species. This reaction takes place stereospecifically
with
retention of configuration at phosphorus, which can produce various
new optically active phosphorus analogues of α-amino acids.