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Cantharimide and Its Derivatives from the Blister Beetle Mylabris phalerata Palla

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posted on 26.07.2016, 18:11 by Yao-Bo Zeng, Xiao-Ling Liu, Yi Zhang, Chuang-Jun Li, Dong-Ming Zhang, Yao-Zong Peng, Xing Zhou, Hong-Fei Du, Chun-Bing Tan, Yu-Yu Zhang, Da-Jian Yang
Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (13), five 1,2-dimethyl cantharimide-type derivatives (4, 5, 79), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (1012), together with seven known cantharimides (6, 1318), were isolated from Mylabis phalerata Palla. The planar structures and absolute configurations of compounds 114 were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds 6, 15, 16, and 18 were found to be potent inhibitors of HBV virus, with IC50 values of 62, 42, 58, and 19 μM.