American Chemical Society
np6b01018_si_002.cif (16.12 kB)

Bufospirostenin A and Bufogargarizin C, Steroids with Rearranged Skeletons from the Toad Bufo bufo gargarizans

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posted on 2017-03-02, 23:03 authored by Hai-Yan Tian, Li-Jun Ruan, Tong Yu, Qing-Fei Zheng, Nan-Hao Chen, Rui-Bo Wu, Xiao-Qi Zhang, Lei Wang, Ren-Wang Jiang, Wen-Cai Ye
Bufospirostenin A (1) and bufogargarizin C (2), two novel steroids with rearranged A/B rings, were isolated from the toad Bufo bufo gargarizans. Compound 1 represents the first spirostanol found in animals. Compound 2 is an unusual bufadienolide with a cycloheptatriene B ring. Their structures were elucidated by spectroscopic analysis, single crystal X-ray diffraction analysis, and computational calculations.