np6b01018_si_002.cif (16.12 kB)
Bufospirostenin A and Bufogargarizin C, Steroids with Rearranged Skeletons from the Toad Bufo bufo gargarizans
dataset
posted on 2017-03-02, 23:03 authored by Hai-Yan Tian, Li-Jun Ruan, Tong Yu, Qing-Fei Zheng, Nan-Hao Chen, Rui-Bo Wu, Xiao-Qi Zhang, Lei Wang, Ren-Wang Jiang, Wen-Cai YeBufospirostenin A (1) and bufogargarizin C (2), two novel steroids with
rearranged A/B rings, were isolated
from the toad Bufo bufo gargarizans. Compound 1 represents the first spirostanol found in animals. Compound 2 is an unusual bufadienolide with a cycloheptatriene B ring.
Their structures were elucidated by spectroscopic analysis, single
crystal X-ray diffraction analysis, and computational calculations.
