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Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

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posted on 19.07.2018, 18:32 authored by Simon Grélaud, Phillippa Cooper, Lyman J. Feron, John F. Bower
Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C–H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible.