Boron Trifluoride Etherate Functioning as a Fluorine Source in an Iodosobenzene-Mediated Intramolecular Aminofluorination of Homoallylic Amines
dataset
posted on 2014-03-07, 00:00 authored by Jian Cui, Qun Jia, Ruo-Zhu Feng, Shan-Shan Liu, Tian He, Chi ZhangA widely used Lewis acid BF3·Et2O was
shown to be capable of acting as an efficient fluorinating agent in
an intramolecular aminofluorination reaction of homoallylic amines
to provide 3-fluoropyrrolidines mediated by a commercially available
hypervalent iodine(III) reagent PhIO at room temperature. A mechanism
involving a carbocation intermediate was proposed on the basis of
several experimental evidence.
