American Chemical Society
ol5031734_si_002.cif (460 kB)

Boron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M

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posted on 2014-12-05, 00:00 authored by Yuto Sumida, Ryu Harada, Tomoe Kato-Sumida, Kohei Johmoto, Hidehiro Uekusa, Takamitsu Hosoya
An efficient synthetic method for versatile dibenzoxaborins based on boron-selective Suzuki–Miyaura cross-coupling between o-borylphenols and aryl halides or triflates bearing a 1,8-diamino­naph­thalene-protected o-boryl group is reported. A short synthesis of defucogilvocarcin M was achieved using the proposed method in combination with several other boron-mediated transformations.