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Biomimetic Synthesis of Lankacidin Antibiotics

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posted on 30.08.2017, 00:00 by Kuan Zheng, Defeng Shen, Ran Hong
We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antibiotic and antitumor agents.