np5b00781_si_002.cif (1.06 MB)

Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi

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posted on 25.11.2015, 00:00 by Chunfeng Xie, Lingmei Sun, Kai Liao, Sheng Liu, Meicheng Wang, Jing Xu, Mark Bartlam, Yuanqiang Guo
Two new ent-pimarane (1 and 2), eight new ent-abietane (310) diterpenoids, and eight known analogues (1118) were isolated from the whole plants of Chloranthus henryi. The absolute configuration of 1 was determined on the basis of single-crystal X-ray diffraction data. Compound 8 represents a class of rare naturally occurring C-14 norabietanes, and compounds 9 and 10 feature rare 13,14-seco-abietane skeletons. Compounds 5, 12, 13, and 15 inhibited the yeast-to-hyphae transition of Candida albicans with IC50 values between 97.3 and 738.7 μM.