ol5030579_si_001.cif (44.1 kB)

Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii

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posted on 19.12.2014, 00:00 by Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue, Yonghui Zhang
Hyperisampsins A–D (14), with tetracyclo­[,10.03,7]­tridecane skeletons and seven biogenetically related congeners (511), were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. The absolute configuration of 1 was established by ECD calculations, and those of 5 and 9 were confirmed by single X-ray crystallographic analyses. Hyperisampsins A and D showed potent anti-HIV activities with EC50 of 2.97 and 0.97 μM and selectivity index of 4.80 and 7.70, respectively.